|
rs200329677
|
|
|
0.010 |
GeneticVariation |
BEFREE |
WNT7B SNPs located in the same genomic region that includes rs9330813 have previously been associated with CCT in Latinos but with other ocular quantitative traits related to myopia (corneal curvature and axial length) in a Japanese population (rs10453441 and rs200329677).
|
29847655 |
2018 |
|
rs10453441
|
|
|
0.020 |
GeneticVariation |
BEFREE |
WNT7B SNPs located in the same genomic region that includes rs9330813 have previously been associated with CCT in Latinos but with other ocular quantitative traits related to myopia (corneal curvature and axial length) in a Japanese population (rs10453441 and rs200329677).
|
29847655 |
2018 |
|
rs9330813
|
|
|
0.010 |
GeneticVariation |
BEFREE |
WNT7B SNPs located in the same genomic region that includes rs9330813 have previously been associated with CCT in Latinos but with other ocular quantitative traits related to myopia (corneal curvature and axial length) in a Japanese population (rs10453441 and rs200329677).
|
29847655 |
2018 |
|
rs10860860
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated whether the IGF-1 single nucleotide polymorphisms (SNPs) rs6214, rs10860860, and rs2946834 are associated with HM (≤-6.0 diopters [D]) and any myopia (≤-0.5 D) phenotype in Polish families.
|
21976954 |
2011 |
|
rs6214
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We investigated whether the IGF-1 single nucleotide polymorphisms (SNPs) rs6214, rs10860860, and rs2946834 are associated with HM (≤-6.0 diopters [D]) and any myopia (≤-0.5 D) phenotype in Polish families.
|
21976954 |
2011 |
|
rs10453441
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta=3.9 × 10(-13)) and corneal curvature (Pmeta=2.9 × 10(-40)) and confirm the previously reported association between GJD2 and myopia.
|
25823570 |
2015 |
|
rs669676
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that in the univariate analysis that both single-nucleotide polymorphisms in COL8A1 gene (rs13095226 and rs669676) together with age, sex and hypertension were significantly associated with myopic CNV development in Spanish patients (p<0.05).
|
27643879 |
2016 |
|
rs79002828
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found rs2973644 was significantly associated with increased risk of myopia (odds ratio [OR]: 1.26; 95% confidence intervals [CI]: 1.06-1.49; P = 0.009). furthermore, rs339501 (OR: 1.73; 95% CI: 1.18-2.53; P = 0.005), rs2973644 (OR: 1.57; 95% CI: 1.13-2.19; P = 0.007), and rs79002828 (OR: 1.83; 95% CI: 1.20-2.77; P = 0.005) were significantly associated with increased risk of high myopia in young children.
|
31021460 |
2019 |
|
rs339501
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We found rs2973644 was significantly associated with increased risk of myopia (odds ratio [OR]: 1.26; 95% confidence intervals [CI]: 1.06-1.49; P = 0.009). furthermore, rs339501 (OR: 1.73; 95% CI: 1.18-2.53; P = 0.005), rs2973644 (OR: 1.57; 95% CI: 1.13-2.19; P = 0.007), and rs79002828 (OR: 1.83; 95% CI: 1.20-2.77; P = 0.005) were significantly associated with increased risk of high myopia in young children.
|
31021460 |
2019 |
|
rs2973644
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found rs2973644 was significantly associated with increased risk of myopia (odds ratio [OR]: 1.26; 95% confidence intervals [CI]: 1.06-1.49; P = 0.009). furthermore, rs339501 (OR: 1.73; 95% CI: 1.18-2.53; P = 0.005), rs2973644 (OR: 1.57; 95% CI: 1.13-2.19; P = 0.007), and rs79002828 (OR: 1.83; 95% CI: 1.20-2.77; P = 0.005) were significantly associated with increased risk of high myopia in young children.
|
31021460 |
2019 |
|
rs2839471
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We did not find evidence for the association of myopia with rs577948, rs11218544, or rs2839471 in the Chinese population studied.
|
22194655 |
2011 |
|
rs577948
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We did not find evidence for the association of myopia with rs577948, rs11218544, or rs2839471 in the Chinese population studied.
|
22194655 |
2011 |
|
rs12603825
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We demonstrated a marginal association of the PEDF SNP, rs12603825, with myopic CNV in extremely myopic patients.
|
23722394 |
2013 |
|
rs1550094
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We also found evidence of association with spherical equivalent on 2q37.1 in PRSS56 at rs1550094 (MAF = 31%, β = -0.33, p = 1.7 × 10(-3)), a region previously associated with myopia.
|
27440996 |
2016 |
|
rs6214
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To investigate the effect of the insulin-like growth factor-1 (IGF-1) gene's rs6214 and rs5742632 polymorphisms on IGF-1 expression levels and their association with different types of myopia in Egyptian patients.
|
27167306 |
2016 |
|
rs3760753
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three single nucleotide polymorphisms (SNPs) [RDH851 (rs2233789), RDH8E5a (rs1644731), and RDH855b (rs3760753)] were selected, based on the linkage disequilibrium pattern of RDH8 from a previous study, and genotyped for 160 Han Chinese nuclear families with highly myopic (-10 diopters or worse) offspring as well as in an independent group with 166 highly myopic cases (-10 diopters or worse) and 211 controls.
|
21043051 |
2010 |
|
rs1644731
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three single nucleotide polymorphisms (SNPs) [RDH851 (rs2233789), RDH8E5a (rs1644731), and RDH855b (rs3760753)] were selected, based on the linkage disequilibrium pattern of RDH8 from a previous study, and genotyped for 160 Han Chinese nuclear families with highly myopic (-10 diopters or worse) offspring as well as in an independent group with 166 highly myopic cases (-10 diopters or worse) and 211 controls.
|
21043051 |
2010 |
|
rs2233789
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three single nucleotide polymorphisms (SNPs) [RDH851 (rs2233789), RDH8E5a (rs1644731), and RDH855b (rs3760753)] were selected, based on the linkage disequilibrium pattern of RDH8 from a previous study, and genotyped for 160 Han Chinese nuclear families with highly myopic (-10 diopters or worse) offspring as well as in an independent group with 166 highly myopic cases (-10 diopters or worse) and 211 controls.
|
21043051 |
2010 |
|
rs339501
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Three FGF10 SNPs in complete linkage disequilibrium--rs339501, rs12517396, and rs10462070--were associated with extreme myopia in the Japanese population, and the risk allele of rs339501 differed from the previous Chinese population.
|
24265547 |
2013 |
|
rs10462070
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three FGF10 SNPs in complete linkage disequilibrium--rs339501, rs12517396, and rs10462070--were associated with extreme myopia in the Japanese population, and the risk allele of rs339501 differed from the previous Chinese population.
|
24265547 |
2013 |
|
rs12517396
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three FGF10 SNPs in complete linkage disequilibrium--rs339501, rs12517396, and rs10462070--were associated with extreme myopia in the Japanese population, and the risk allele of rs339501 differed from the previous Chinese population.
|
24265547 |
2013 |
|
rs644242
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This study provides additional evidence suggesting that the <i>PAX6</i> SNP rs644242 is associated with extreme myopia but not lower grade myopia.
|
29436400 |
2018 |
|
rs2010963
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This association was successfully replicated in the additional 76 eyes with myopic CNV, and pooled analysis revealed significant association of rs2010963 with CNV size (P = 0.00078).
|
22427559 |
2012 |
|
rs7744813
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The SNP rs7744813, previously shown to be associated with refractive error and myopia in two GWAS, showed an odds ratio of 0.75 (95% CI 0.63-0.90; <i>P</i><sub>emp</sub> = 0.0058) for the minor allele.
|
28884119 |
2017 |
|
rs634990
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The risk of myopia versus hyperopia was OR 1.88 (95 % CI 1.64, 2.16, P < 0.001) for homozygous carriers of the risk allele at the top SNP rs634990, and OR 1.33 (95 % CI 1.19, 1.49, P < 0.001) for heterozygous carriers.
|
22665138 |
2012 |